FIELD: medicine, immunotherapy. SUBSTANCE: invention relates to vaccine showing effectiveness for inhibition of cerebrospinal sclerosis, method for inducing immune response. Invention involves vaccine containing attenuated T-cells grown in the presence of myelin proteins, in part, in the presence of bovine proteins. In preferable variant of invention vaccine comprises attenuated T-cells prepared by culturing autological circulating mononuclear cells in the presence of bovine total myelin proteins by selection and multiplication of T-cells with immune response for myelin proteins and attenuation of cells by irradiation. The advantage of invention involves the development of effective nontoxic agent for treatment of patients with primary or secondary cerebrospinal sclerosis. EFFECT: valuable medicinal properties of vaccine. 18 cl, 14 dwg, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| VIRUS OF CAPRINE ARTHRITIS-ENCEPHALITIS PROVIDING IMMUNE PROTECTION AGAINST HIV- 1 INFECTION | 1997 |
|
RU2194529C2 |
| RELEASE AND IDENTIFICATION OF T-CELLS | 2003 |
|
RU2327487C2 |
| DESIGNATION AND APPLYING GENES ENCODING PATHOGENIC EPITOPES FOR TREATMENT OF AUTOIMMUNE DISEASE | 1997 |
|
RU2248807C2 |
| METHOD FOR PRODUCTION OF POLYCLONAL T-CELL VACCINE USEFUL IN TREATMENT OF IMMUNOLOGICAL DISORDERS | 2004 |
|
RU2277422C2 |
| MATERIALS AND METHODS REFERRING TO T-CELLULAR VACCINES | 2002 |
|
RU2302257C2 |
| METHOD FOR APPLICATION OF ZOT AND ZONULIN FOR INHIBITION OF ANTIGEN-SPECIFIC PROLIFERATION OF LYMPHOCYTES | 1999 |
|
RU2214271C2 |
| PEPTOID LIGANDS FOR AUTOIMMUNE T-CELL RECOVERY AND PROCESSING | 2010 |
|
RU2563822C2 |
| THERAPY OF INFLAMMATORY DISEASES | 2007 |
|
RU2440110C2 |
| METHOD OF ESTIMATING ANTI-ERGOTYPIC RESPONSE IN EXPERIMENT | 2009 |
|
RU2423079C1 |
| PEPTIDE FROM THE COMPOSITION OF THE IMMUNOGLOBULIN HUMAN HEAVY CHAIN, SUITABLE FOR TREATMENT OF MULTIPLE SCLEROSIS | 2016 |
|
RU2646817C1 |
