METHOD FOR APPLICATION OF ZOT AND ZONULIN FOR INHIBITION OF ANTIGEN-SPECIFIC PROLIFERATION OF LYMPHOCYTES Russian patent published in 2003 - IPC

FIELD: medicine, immunology. SUBSTANCE: invention relates to inhibition of lymphocytes proliferation. Method involves the use of Zot-toxin from zone of narrow contacts producing by V. cholerae or zonulin the preparation of mammalian proteins that are related to Zot immunologically or functionally. The inhibition effect elicits both in cell culture treated with antigen and, hypothetically, under conditions of mammal body. Method provides significant inhibition of sensitized lymphocytes due to antigen blocking. EFFECT: enhanced inhibition method. 16 cl, 13 dwg