FIELD: pharmaceutical chemistry. SUBSTANCE: invention relates to compositions and methods for treating cancerous patients, wherein compounds of formula I: R1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)u-K (I), which are dolastatin-15 derivatives, combined with paclitaxel, taxoter, or analogs of modified taxane or taxoid manifest enhanced anticancer effects compared to effects shown by using these compounds taken separately. EFFECT: increased anticancer effect. 30 cl, 1 dwg, 5 tbl, 6 ex
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