DERIVATIVES OF 11-ACETYL-12,13-DIOXABICYCLO[8,2,1]- TRIDECENONE, METHOD FOR THEIR PREPARING AND MEDICINAL AGENT COMPRISING THESE COMPOUNDS Russian patent published in 2003 - IPC

Abstract RU 2218346 C2

FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention relates to derivatives of (2R,3S,4S,5R,6R,10R,11R)-2,4,6,8,10-pentamethyl-11-acetyl- 12,13-dioxabicyclo[8.2.1] tridec-8-ene-1-one of the general formula (I) wherein R¹ means hydrogen atom or methyl; R² means hydrogen atom or lower alkyl and to their physiologically acceptable acid additive salts also. Method for preparing compounds involves oxidative cleavage of glycol in by-side 2',3'-dihydroxypent-2-yl chain at position 11 of cyclic structure of compound of the formula (II) wherein R¹ and R² have above given values. Invention proposes also a medicinal agent useful for treatment of motor system disorders in digestive tract, gastroparesis, disorders in stomach evacuation, gastroesophagial reflux and/or dyspepsia containing effective amount of compound and pharmaceutical accessory substances and/or carriers. EFFECT: improved preparing methods, valuable medicinal properties of compounds. 5 cl, 1 tbl

Similar patents RU2218346C2

Title	Year	Author	Number
DERIVATIVES OF 10,13,15-TRIOXATRICYCLO-9.2.1.1.-PENTADECANONE, METHOD OF THEIR SYNTHESIS AND MEDICINAL AGENTS CONTAINING THESE COMPOUNDS	1997	Khelt'E Dagmar Projshoff Ul'F Ehkkhout Kristian Finner Ehmil'	RU2181727C2
DERIVATIVES OF [2R,3R(2′R,3′R),6R,7S,8S,9R,10R]-3-(2′,3′-DIHYDROXYPENT-2′-YL)- -2,6,8,10,12-PENTAMETHYL-4,13-DIOXOBICYCLO [8,2,1]-TRIDEC-12-ENE-5-ON, METHOD FOR THEIR PRODUCTION, PHARMACEUTICAL AGENT	1992	Dagmar Khel'T'E[De] Ulf Projshoff[De] Kristian Ehkkhout[Nl]	RU2107070C1
IMMUNOMODULATORY AZALIDES BASED ON UREA	2021	Cox Mark R. Stuk Timothy L. Maddux Todd M. Ewin Richard Andrew Johnson Paul D. Respondek Tomasz Kyne Graham M. Vairagoundar, Rajendran	RU2811591C1
APPLICATION OF EPOTHILONES IN TREATMENT OF BRAIN DISEASES ASSOCIATED WITH PROLIFERATIVE PROCESSES	2003	Likhtner Rozemari Rotgeri Andrea Klar Ul'Rikh Khoffmann Jens Bukhmann Bernd Shvede Vol'Fgang Skuballa Verner	RU2351330C2
C-ARYL GLUCOSIDE DERIVATIVES, PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF	2011	Yan Fanlun Tan Pen Chzho Dun Tsin Tu Vanyan Fan Tszyan Guan Dunlyan Shen Guanyuan Van Yan Yuan Tszitszyun Chzhan Limin	RU2606501C2
SHIP1 MODULATORS AND METHODS RELATED THERETO	2014	Makkenzi Llojd F. Makruri Tomas B. Kharvig Kertis Bogutski Devid Rejmond Dzheffri R. Pettigryu Dzheremi D.	RU2679805C2
METHOD FOR PREPARING 4''-SUBSTITUTED DERIVATIVES OF 9-DEOXO-9A-AZA-9A-HOMOERYTHROMYCIN A	2002	Sklavounos Konstantin Taker Dzhon Llojd Vej Lulin Mehjkhon Kerri Piter Ml. Khammen Filip Ditrikh Negri Dzhoanna Tereza Lener Richard Shelton	RU2263117C2
MODIFIED C-21-EPOTHILONES	2000	Khoehfle Gerkhard Glazer Nikol' Lajbol'D Tomas Vite Gregori Kim Sung-Khun	RU2253652C2
DERIVATIVES OF CYCLOHEXANE OR TETRAHYDROPYRANE OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS, OR HYDRATES, OR SOLVATES OF THESE COMPOUNDS, OR THEIR SALTS, INTERMEDIATE COMPOUNDS FOR THEIR SYNTHESIS AND FUNGICIDE AGENT	1992	Jukhko Aoki[Jp] Khiromichi Kotaki[Jp] Katsunao Masubuchi[Jp] Toru Okuda[Jp] Nobuo Shimma[Jp] Takuo Tsakuda[Jp] Isao Umeda[Jp]	RU2084439C1
CYTOSKELETON-ACTIVE COMPOUNDS, COMPOSITIONS AND USE	2006	Lampe Dzhon V. Plaurde Robert Ml. Sheh Tszin' Vittitou Dzhejson L. Vatson Pol S. Krimmins Majkl T. Slejd Dehvid Dzh.	RU2407745C2

RU 2 218 346 C2

Authors

Zhasseran Daniel'

Projshoff Ul'F

Ehkkkhaut Kristian

Dates

2003-12-10—Published

1999-02-12—Filed