COMPATIBLE TWO-COMPONENT SYSTEM DESIGNATED FOR APPLICATION IN MAMMAL-HOST AS MEDICINAL AGENT (VARIANTS), METHOD FOR DELIVERY OF CYTOTOXIC DRUG Russian patent published in 2003 - IPC

FIELD: genetic engineering, medicine, pharmacy. SUBSTANCE: invention relates to agents of genetic therapy. Invention proposes compatible two-component system. The first component comprises gene construction encoding cell-recognizing radical and representing anti-CEA antibody and heterologous enzyme carboxypeptidase activating drug. The second component represents prodrug transforming to cytotoxic drug by enzyme carboxypeptidase. Prodrug is taken among group representing N-{4-[N,N-bis-(2-iodoethyl)amino]phenoxy- carbonyl} -L-glutamic acid, gamma-(3,5-dicarboxy)anilide N-{4-[N,N-bis-(2-chloroethyl)amino] - phenoxycarbonyl}-L-glutamic acid or their pharmaceutically acceptable salts. Except for, invention proposes method for delivery of cytotoxic drug to designation point providing administration to the mammal-host of the first component of system and the following administration to the host the second component. Proposed invention allows carrying out the more selective gene-directed enzymatic prodrug therapy and to reduce undesirable effect in normal tissues in the case of mistaken activation of prodrug. Invention can be used in medicine for carrying out antitumor gene-directed enzymatic prodrug therapy. EFFECT: valuable medicinal properties of system, enhanced effectiveness of drug delivery. 9 cl, 6 dwg, 23 ex