FIELD: veterinary parasitology. SUBSTANCE: composition comprises at least one first active substance combined with at least one second active substance and specific additives. First active substance is selected in the group consisting of avermectin, 22,23- dihydroavermectin B1 (ivermectin) and milbemycin of macrocyclic lactones class. Second active substance is selected in the group consisting of agonist and antagonist of nicotinoergic acetylcholine receptors of insects of general formulation (III): where R is hydrogen, unsubstituted or substituted residues selected in the group consisting of acyl, alkyl, aryl, aralkyl, heteroaryl, and heteroarylalkyl, A is monofunctional group of chain including hydrogen, acyl, alkyl, aryl, or bifunctional group, which is combined with Z residue; E is electron-seeking residue; X are -C= or =N residues, where -CH= residue may be combined with Z residue instead of hydrogen atom; Z is monofunctional group of alkyl chain, -O-R, -S-R, or is bifunctional group combined with A residue or X residue. Composition is nontoxic. EFFECT: increased efficiency and improved antiendoparasitic and antiectoparasitic activity. 4 cl, 6 tbl, 11 ex
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Authors
Dates
2004-01-27—Published
1997-12-11—Filed