FIELD: medicine, biochemistry, pharmacy. SUBSTANCE: invention proposes percutaneous therapeutic plaster comprising self-gluing matrix layer based on organosilicon compound or polyacrylate with at least one active substance as an inhibitor of hydroxymethylglutaryl-CoA-reductase being a matrix layer is covered with backing that is impermeable for the active substance. The substance with structural elements of tetrahydro-4-hydroxy-6-oxo-2H-pyrane (for example, lovastatin) is used as an inhibitor of hydroxymethylglutaryl-CoA-reductase. Invention provides the sustained-release of active substance with absolute availability. EFFECT: valuable properties medicinal and pharmaceutical of composition. 9 cl, 3 ex
