DERIVATIVES OF AMINES OR AMIDES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD FOR ANTAGONIZING RECEPTOR Y5 OF NEUROPEPTIDE NPY Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new derivatives of amines or amides of the general formula (A): wherein R₁ means hydrogen atom, hydroxy-group, halogen atom, C_1-8-alkyl, C_1-8-alkoxy-group, trifluoro-alkyl, C_1-8-alkylthio-group; n = 1-2; B₁ and B₂ mean hydrogen atom; either B₁ and B₂ represent methylene and taken in common they form six-membered ring; or one of B₁ and B₂ represents hydrogen atom while the second represents methylene and taken in common they form five-membered ring; m = 0-3; R₂ means hydrogen atom, hydroxy-group, C_1-6-alkyl, C_2-6-alkenyl, halogen atom, C_3-7-cycloalkyl, phenyl and others; L means C_1-8-alkylene, C_2-10-alkenylene, C_2-10-alkynylene, C_3-7cycloalkylene and others; Y means methylene or carbonyl; Z means aryl, N-sulfoneamido-group, arylamido-group, arylureido-group and others; R₃ means C_1-6-alkyl, cycloalkyl, naphthyl, heteroaryl and others; R₄ means hydrogen atom, C_1-8-alkyl, C_1-8- alkoxy-group, hydroxy-group, halogen atom, cyano-group and others; R₅ means hydrogen atom, C_1-8-alkyl, C_1-8-alkylcarbonyl, aroyl, carbamoyl and others; R₆ means hydrogen atom or C_1-8-alkyl; p and q = 1-3. Compounds of the formula (A) represent ligands for receptor Y5 of neuropeptide NPY and can be used in medicine for treatment of disturbances in central nervous system. EFFECT: valuable medicinal properties of compounds. 15 cl, 2 tbl, 14 ex