N-SUBSTITUTED AMINOTETRALINES AS LIGANDS FOR RECEPTOR OF Y5 OF NEUROPEPTIDE Y USEFUL IN TREATMENT OF OBESITY AND OTHER DISORDERS Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to N-substituted aminotetralines of the formula (I): wherein R¹ is taken independently among the group consisting of hydrogen atom, hydroxy-group, halogen atom, C_1-8--alkoxy-group, substituted C_1-8--alkoxy-group wherein substituent represents halogen atom; n = 0-2; Y represents methylene; m = 0-3; B₁ represents hydrogen atom; B₂ represents hydrogen atom; R₂ is taken among the group consisting of hydrogen atom, hydroxy-group, C_1-6-alkyl, C_1-6-alkenyl, phenyl, substituted phenyl wherein substituent is taken among halogen atom, C_1-6-alkyl, C_1-6--alkoxy-group, trifluoro-C_1-6-alkyl, nitro-group, naphthyl and pyridyl; L is taken among the group consisting of C_1-8-alkylene, C_1-4-alkylene-C_3-7-cycloalkyl-C_1-4-alkylene, C_1-4--alkylenearyl-C_1-4-alkylene; R₃ is taken among phenyl, substituted phenyl where substituent is taken among halogen atom, nitro-group, C_1-8-alkoxy-group, trifluoromethyl group and amino-C_1-8-alkyl, naphthyl and thienyl; and their enantiomers, diastereoisomers and pharmaceutically acceptable salts. Compounds of the formula (I) are ligands of receptor Y5 of neuropeptide Y that allows their using in pharmaceutical composition for treatment of diseases and disorders associated with inhibition of subtype Y5 of receptor NPY. EFFECT: valuable medicinal properties of compounds. 20 cl, 3 tbl, 9 ex