THIENOPYRIMIDINE COMPOUNDS AND THEIR APPLICATION Russian patent published in 2008 - IPC C07D495/04 A61K31/519 A61P5/04 

FIELD: chemistry, pharmaceuticals.

SUBSTANCE: invention pertains to derivatives of thienopyrimidine with general formula I , where R¹ represents C_1-4alkyl; R² represents C_1-6alkyl, possibly substituted (1') by a hydroxyl group, (2') C_1-4alkoxy, (3') C_1-4alkoxycarbonyl, (4') di-C_1-4alkylcarbamoil, (5') 5-6-member nitrogen containing heterocyclic group, (6') C₁-C₄alkylcarbonyl and (7') halogen, 5-6-member nitrogen containing heterocyclic group, phenyl, which can contain a substitute, R³ - C_1-4alkyl, R⁴ - C_1-4alkoxy. The compounds have antagonist activity to gonadotropin releasing hormones (GnRH). Description is given of a medicinal preparation based on formula I compounds, used of the compounds in making pharmaceutical compositions and the antagonist effect of the compounds on gonadotropin releasing hormone.

EFFECT: obtaining derivatives of thienopyrimidine with antagonist effect on gonadotropin releasing hormones.

17 cl, 143 ex