SUBSTITUTED 3,7-DIAZABICYCLO[3,3,1]NONANES, FOCUSED LIBRARY AND COMBINATORY LIBRARY Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacology. SUBSTANCE: invention relates to new enantiomeric, diastereomeric or stereoisomeric 3,7- diazabicyclo[3.3.1]nonanes of the general formula (1) as bases or salts of pharmacologically acceptable acids that showed in testing high activity with respect to nicotine receptors. Invention relates also to the focused and combinatory libraries of these compounds. In compounds of the formula (1) R¹ represents ; each among R², R³, R⁵, R⁶ represents independently hydrogen atom, inert substituent, NH-protective substituent, electrophilic substituent, nucleophilic substituent; R² and R³ represent in common: -C(O)-, -C(S)-, -C(O)- C(O)-, -CHR⁸-, -(CH₂)_k-CR⁷R⁸, S(O)_n, n = 1, 2; k = 1-3; R¹ and R³ or R¹ and R² represent in common group C=O; R⁴ represents halogen atom, sulfonyloxy-group (for example, tosyl group) or acyloxy-group (for example, acetate); NR⁵R⁶ represent in common azaheterocyclyl or substituted azaheterocyclyl; R⁷ and R⁸ each represents independently: hydrogen atom, inert substituent. EFFECT: valuable medicinal and pharmacological properties of compounds. 35 cl, 1 tbl, 15 ex