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Application

2003125344/04, 2003-08-20

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Start date

2003-08-20

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Actual filing date

2003-08-20

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Published

2005-09-27

(72)

Inventor

Zhuravel' Irina AleksandrovnaIvashchenko A.V.Kovalenko Sergej NikolaevichTkachenko S.E.Chernykh V.P.Okun' Il'Ja Matusovich

(73)

Holder

Ooo Institut Khimicheskogo Raznoobrazija"

SUBSTITUTED 2H-PYRANO[2,3-C]PYRIDINES, COMBINATORY AND FOCUSED LIBRARIES Russian patent published in 2005 - IPC

Abstract RU 2261251 C2

FIELD: organic chemistry, pharmacy, biochemistry.

SUBSTANCE: invention relates to new substituted 2H-pyrano[2,3-c] of the general formula (1) eliciting ability to inhibit activity of protein kinase. In the general formula (1) X represents oxygen atom or group NR³; R¹ represents group -C(O)R⁴, optionally substituted and optionally condensed azaheterocycle; R² represents optionally substituted hydroxyl group or optionally substituted amino-group; R³ represents hydrogen atom or inert substitute meaning optionally substituted low- or non-reactive radical including such as (C₁-C₇)-alkyl, (C₂-C₇)-alkenyl, (C₂-C₇)-alkynyl, (C₁-C₇)-alkoxy-group, (C₇-C₁₂)-aralkyl, heterocyclylalkyl, (C₇-C₁₂)-alkaryl, (C₃-C₁₀)-cycloalkyl, (C₃-C₁₀)-cycloalkenyl, phenyl, aryl, (C₂-C₁₂)-alkoxyalkyl, (C₂-C₁₀)-alkylsulfinyl, (C₂-C₁₀)-alkylsulfonyl, -(CH₂)-O-(C₁-C₇-alkyl), -(CH₂)_m-N(C₁-C₇-alkyl)_n, aryloxyalkyl, heterocyclyl wherein m and n have value from 1 to 7; R⁴ represents optionally substituted amino-group or hydrogenated optionally substituted azaheterocycle. Also, invention relates to combinatory and focused libraries consisting of compounds of the present invention and designated for the search of compound-hits and compound-leaders prepared by screening of these libraries for using in preparing medicinal agents.

EFFECT: valuable medicinal properties of compounds.

8 cl, 2 tbl, 6 ex

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RU 2 261 251 C2

Authors

Zhuravel' Irina Aleksandrovna

Ivashchenko A.V.

Kovalenko Sergej Nikolaevich

Tkachenko S.E.

Chernykh V.P.

Okun' Il'Ja Matusovich

Dates

2005-09-27—Published

2003-08-20—Filed