DERIVATIVES OF 7-ARYL-3,9-DIAZABICYCLO(3,3,1)NON-6-ENE-RHENIN INHIBITORS Russian patent published in 2009 - IPC C07D471/08 C07D487/08 C07D493/08 C07D495/08 A61P9/00 

FIELD: chemistry.

SUBSTANCE: derivatives of 7-aryl-3,9-diazabicyclo(3.3.1)non-6-ene of general formula I , general formula I, where X and W or both represent -CH-, or one of them represents -CH-, and the other -N. V represents -A-(CH₂)_s-, -(CH₂)_s-A-, -A-(CH₂)_v-B- or -CH₂-A-(CH₂)₃-B-; A and B represent-O- U -phenyl, possibly 1-3 substituted with halogen, alkyl, alkoxy, CF3, CF3O - or alkylcarbonyl, or pyridyl, monosubstituted with cyanogroup. T represents -CONR¹-, -(CH₂)_pOCO- or -(CH₂)_pN(R¹)CO- Q-alkylene; M - hydrogen, phenyl, possibly substituted, benzo[1,3]dioxol, possibly substituted, or pyridyl; L represents -R³, -COR³, -COOR³, -CONR²R³ or -SO₂R³; R¹ - hydrogen, alkyl, C_3-7 cycloalkyl, pyrrolidinyl, benzo[b]thienyl, chinoxalinyl, phenylalkyl, thienylalkyl or tetrazolylalkyl, possibly substituted. m=1, n=0 or m=0, n=1, p - integer 1-4, s - integer 2-5, v - integer 2-4, optically pure enantiomers, mixtures of enantiomers, pharmaceutically acceptable salts and complexes with solvents, possessing activity of phenin inhibitors.

EFFECT: efficient application in medicine for treatment of cardio-vascular diseases and renal failure.

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