MEDICINAL COMBINATION COMPRISING (E)-7-[4-(4-FLUOROPHENYL)-6-ISOPROPYL-2-[METHYL(METHYLSULFONYL)AMINO]PYRIMIDINE-5-YL]-(3R,5S)-3,5-DIHYDROXYHEPT-6-ENOIC ACID AND INHIBITOR, INDUCTOR OR SUBSTRATE FOR P-450 3A4 ISOZYME Russian patent published in 2004 - IPC

FIELD: organic chemistry, biochemistry, medicine, pharmacy.

SUBSTANCE: invention relates to non-interacting combination of medicinal agents comprising HMG-CoA-reductase inhibitor that represents (E)-7-[4-(4-fluorophenyl)-6-isopropyl-[methyl(methylsulfonyl)amino]-pyrimidine-5-yl]-(3R,5S)-3,5-dihydroxyhept-6-enoic acid or its pharmaceutically acceptable salt, and medicinal agent that represents inhibitor, inductor or substrate for cytochrome P-450 3A4 isozyme. The combination is used in treatment of hyperlipidemia in humans in the process of immunosuppressive chemotherapy treatment. The combination doesn't cause adverse responses in patent determined by metabolism of a medicinal agent with P-450 dependent enzyme.

EFFECT: valuable medicinal properties of agent.

15 cl, 1 tbl, 1 ex