FIELD: biotechnology, protein genetic engineering, molecular biology, veterinary science.
SUBSTANCE: invention relates to vaccine used in veterinary practice. Vaccine against swine pleuropneumonia involves genetically modified noncapsulated bacterium Actinobacillus pleuropneumoniae that comprises DNA without sequences encoding synthesis of capsule. Also, invention describes a method for preparing the indicated vaccine. Method for preparing vaccine involves identification of DNA sequences in capsule synthesis that encode synthesis of Actinobacillus pleuropneumoniae capsule and the following deleting indicated DNA sequences encoding capsule synthesis to obtain noncapsulated mutants of this microorganism. The prepared recombinant vaccine is safety, effective, live and attenuated.
EFFECT: improved, enhanced and valuable properties of vaccine.
4 cl, 2 tbl, 14 dwg, 1 ex
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