FIELD: molecular biology, genetic engineering, microbiology, vaccines. SUBSTANCE: invention relates to a method of isolation of a nucleotide sequence encoding protein (molecular mass is 64 000 Da) that is localized on external membrane of N. meningitidis cells and recombinant DNA obtained on said. Invention can be used for diagnosis methods and producing vaccines exhibiting the broad immunoprotection spectrum. EFFECT: identification of the nucleotide sequence encoding highly conservative protein, production of this protein, high purity of the protein. 11 cl, 6 dwg, 10 ex
| Title | Year | Author | Number |
|---|---|---|---|
| NMB1125 PROTEIN AND ITS APPLICATION IN PHARMACEUTICAL COMPOSITIONS | 2004 |
|
RU2336900C2 |
| PROTEIN NMB0928 AND ITS APPLICATION IN PHARMACEUTICAL COMPOSITIONS | 2004 |
|
RU2335505C2 |
| CR3 CHIMERA GENE AND CR3 CHIMERA PROTEIN ENCODED THEREWITH (VARIANTS) INDUCING ANTI-HIV-1 IMMUNE RESPONSE | 2002 |
|
RU2302461C2 |
| KIT FOR PREPARING IMMUNOGENIC COMPOSITION FOR SEROGROUP B Neisseria meningitidis | 2008 |
|
RU2498815C2 |
| VACCINES WITH APPLICATION OF VESICLES BASED ON GNA 1870 OF BROAD SPECTRUM OF ACTION FOR PREVENTION OF DISEASES, CAUSED BY NEISSERIA MENINGITIDIS | 2006 |
|
RU2432962C2 |
| ANTIGENES NEISSERIA MENINGITIDIS | 1999 |
|
RU2343159C2 |
| COMPOSITION FOR TREATMENT OR PROPHYLAXIS OF INFECTION CAUSED BY MICROORGANISM NEISSERIA | 2000 |
|
RU2244749C2 |
| VACCINAL COMPOSITION AGAINST HEPATITIS C VIRUS | 2005 |
|
RU2351363C2 |
| VACCINE COMPOSITION CONTAINING TRANSFERRIN-BINDING PROTEIN AND HSF FROM GRAM-NEGATIVE BACTERIA | 2003 |
|
RU2359696C2 |
| NUCLEIC ACID CODING FUNCTIONALLY ACTIVE RECOMBINANT IgAL PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, RECOMBINANT PLASMID DNA CONTAINING NUCLEOTIDE SEQUENCE CODING ACTIVE IgAL PROTEASE, PRODUCER STRAIN CONTAINING PLASMID DNA PRODUCING MATURE FORM OF IgAL PROTEASE, RECOMBINANT Ig PROTEASE NEISSERIA MENINGITIDIS OF SEROGROUP B, METHOD FOR PRODUCING MATURE FORM IgAL PROTEASE SHOWING IMMUNOGENIC AND PROTECTIVE PROPERTIES | 2011 |
|
RU2453599C1 |
