FIELD: biotechnologies.
SUBSTANCE: invention relates to field of biotechnology, namely to obtaining vaccine strains, and can be used in veterinary. Bacterium Actinobacillus pleuropneumoniae is modified by introducing deletion, of at least one segment of gene apxIA and, optionally, segment of gene apxIIA, which code transmembrane domain of haemolytic and cytolytic exotoxins Apx. Obtained bacterium is used for production of vaccine against pig pleuropneumonia.
EFFECT: invention allows obtaining attenuated live vaccine against pig pleuropneumonia based on immunogenic non-haemolytic strain of bacterium Actinobacillus pleuropneumoniae.
11 cl, 6 dwg, 3 tbl, 1 ex
| Title |
Year |
Author |
Number |
| VACCINE TO PROTECT PIGS FROM ACTINOBACILLUS PLEUROPNEUMONIAE |
2018 |
- Witvliet, Maarten, Hendrik
- Bijlsma, Johanna, Jacoba, Elisabeth
|
RU2750894C1 |
| VACCINE AGAINST PLEUROPNEUMONIA IN ANIMAL, METHOD FOR ITS PREPARING |
1997 |
- Inzehna Tomas Dzh.
- Vehrd Kristin
|
RU2234941C2 |
| PORCINE VACCINE AGAINST PORCINE RESPIRATORY AND REPRODUCTIVE PATHOLOGIES |
2002 |
- Odonne Zhan-Kristof
- Bushardon Annabell'
- Bodju Filipp
- Riv'Er Mishel'
|
RU2305559C2 |
| AVIRULENT STRAIN VIBRIO CHOLERAE OF NON 01-SEROGROUP (VARIANTS), METHOD OF STRAIN PREPARING (VARIANTS), VACCINE |
1994 |
- Kaper Dzhejms
- Levin Majron
|
RU2140981C1 |
| METHOD FOR OBTAINING ACTINOBACILLUS PLEUROPNEUMONIA ApxI OR ApxIII TOXINS IN LIQUID CULTURE MEDIA SUPPLEMENTED BY AIR ENRICHED WITH CARBON DIOXIDE |
2009 |
- Slagman Simen-Jan
- Smits Kristian Teodor Gerardus
|
RU2507267C2 |
| BACTERIUM PRODUCER OF PRODUCT OF REACTION CATALISED BY PROTEIN SHOWING 2-OXOGLUTARATE-DEPENDENT ENZYME ACTIVITY, AND METHOD FOR PRODUCING SUCH PRODUCT |
2008 |
- Smirnov Sergej Vasil'Evich
- Samsonova Natal'Ja Nikolaevna
- Kotljarova Veronika Aleksandrovna
- Rushkevich Natalija Jur'Evna
- Beznoshchenko Ol'Ga Sergeevna
- Bachina Tat'Jana Aleksandrovna
- Imabajasi Juki
- Sugijama Masakazu
- Suzuki Sun"Ichi
|
RU2444568C2 |
| POLYNUCLEOTIDE ENCODING PHOSPHOENOLPYRUVATE CARBOXYKINASE AND PROBE DESIGNATED FOR ITS PREPARING |
2000 |
- Ajkmanns Bernkhard
- Ridel' Kristian
- Zam Germann
- Mekkel' Bettina
|
RU2262532C2 |
| METHOD FOR OBTAINING PYRROLOQUINOLINE QUINONE (PQQ) USING BACTERIUM OF Methylobacterium OR Hyphomicrobium TYPE |
2011 |
- Gak Evgenij Rodionovich
- Gorshkova Natal'Ja Vasil'Evna
- Tokmakova Irina L'Vovna
|
RU2504584C2 |
| MUTANT PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE, DNA CODING SAID SYNTHETASE, BACTERIUM CODING SAID DNA, METHOD OF PRODUCING PURINE NUCLEOSIDES AND METHOD OF PRODUCING PURINE NUCELOTIDES |
2008 |
- Zakataeva Natalija Pavlovna
- Livshits Vitalij Arkad'Evich
- Matsuno Kiesi
- Romanenkov Dmitrij Vladimirovich
- Vitushkina Marija Vjacheslavovna
- Gronskij Sergej Viktorovich
- Kutukova Ekaterina Aleksandrovna
|
RU2403286C2 |
| ESSENTIALLY NON-TOXIC MUTEIN OF Clostridium perfringens ALPHA TOXIN AND NUCLEIC ACID MOLECULE CODING SAME |
2007 |
- Kokren Mark D.
- Petersen Geri
- Lejr Stiven V.
- Sinenki Richard
|
RU2593945C2 |
