METHOD OF OBTAINING IMMUNOGENIC NON-HEMOLYTHIC BACTERIUM OF SPECIES Actinobacillus pleuropneumoniae, BACTERIUM OF SPECIES Actinobacillus pleuropneumoniae, VACCINE AGAINST PIG PLEUROPNEUMONIA (VERSIONS), IMMUNOGENIC AND NON-HAEMOLYTIC STRAIN OF Actinobacillus pleuropneumoniae (VERSIONS) Russian patent published in 2009 - IPC A61K39/102 C12N1/21 A61P31/04 

Abstract RU 2351360 C2

FIELD: biotechnologies.

SUBSTANCE: invention relates to field of biotechnology, namely to obtaining vaccine strains, and can be used in veterinary. Bacterium Actinobacillus pleuropneumoniae is modified by introducing deletion, of at least one segment of gene apxIA and, optionally, segment of gene apxIIA, which code transmembrane domain of haemolytic and cytolytic exotoxins Apx. Obtained bacterium is used for production of vaccine against pig pleuropneumonia.

EFFECT: invention allows obtaining attenuated live vaccine against pig pleuropneumonia based on immunogenic non-haemolytic strain of bacterium Actinobacillus pleuropneumoniae.

11 cl, 6 dwg, 3 tbl, 1 ex

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RU 2 351 360 C2

Authors

Pin'Ol Ribas Khaume

Bru Virkhili Serkhi

Ehspun'Ja Maso Ehnrik

Kerol Murill'O Ehnrike

Dates

2009-04-10Published

2003-11-17Filed