METHOD FOR PREPARING 7-AMINOPYRIDO[1,2-A][1,3]-BENZIMIDAZOLE Russian patent published in 2004 - IPC

Abstract RU 2236409 C1

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for preparing 7-aminopyrido[1,2-a] [1,3]-benzimidazole of the formula (1) that can be used as an intermediate product in synthesis of fluorescent and biologically active substances. Method involves stage for preparing N-(2,4-dinitrophenyl)pyridinium chloride by interaction of 2,4-dinitrochlorobenzene with pyridine and reduction of N-(2,4-dinitrophenyl)pyridinium chloride. Interaction of 2,4-dinitrochlorobenzene with pyridine is carried out at temperature 20^oC for 1 h in the mole ratio 2,4-dinitrochlorobenzene : pyridine = 1:7, and reduction of salt SnCl₂^. 2 H₂O alcoholic solution is carried out in 3% HCl in the mole ratio N-(2,4-dinitrophenyl)pyridinium chloride : SnCl₂^. 2 H₂O = 1:6 at temperature 20^oC for 0.12 h. Invention provides reducing cost of synthesis, diminishing time and temperature in carrying out the process, enhancing purity and the yield of the end product.

EFFECT: improved preparing method.

2 cl, 2 ex

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RU 2 236 409 C1

Authors

Begunov R.S.

Demidova N.Ju.

Krinitsyna G.V.

Abramov I.G.

Smirnov A.V.

Kalandadze L.S.

Dates

2004-09-20—Published

2003-04-24—Filed