COMPOUND, PHARMACEUTICAL COMPOSITION Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention discloses compounds of the formula (I) or their pharmaceutically acceptable salts wherein: dotted line means optional double bond; X¹ means optionally substituted (C₁-C₁₂)-alkyl, (C₃-C₁₂)-cycloalkyl, phenyl, furanyl, thienyl, pyridyl, thiazolyl, 1H-indolyl group; X² means -CHO, -CN, -(CH₂)_vOR¹³, -(CH₂)_vNR²¹R²² or -(CH₂)_vNHC(O)R²¹ wherein v = 0 or 1; or X¹ means optionally substituted heterocyclic group condensed with benzene ring; X² means hydrogen atom; or X¹ and X² form in common optional spiroheterocyclic group condensed with benzene ring; R¹, R², R³ and R⁴ mean independently hydrogen atom (H) and (C₁-C₆)-alkyl group, or (R² and R⁴) can form in common alkylene bridge consisting of 1-3 carbon atoms; Z¹ means substituted phenyl; Z² means substituted phenyl; Z³ means hydrogen atom; or Z¹, Z² and Z³ in common with carbon atom to which they are bound form bicyclic saturated rings. Invention relates also to a pharmaceutical composition based on these compounds. Compounds elicit properties of agonist of nociceptive receptor ORL-1 and can be used in treatment of cough.

EFFECT: valuable medicinal properties of compounds.

10 cl, 4 dwg, 11 tbl, 13 ex