FIELD: organic chemistry, pharmacy.
SUBSTANCE: invention relates to new biologically active compounds that are able to modulate the pharmacological response of one or some opioid receptors taken among ORL-1 and μ-receptors. Invention describes a compound of the formula (I): 
wherein W represents hydrogen atom, (C1-C10)-alkyl, (C1-C4)-alkyl-SO2N(V1)2, cyano-(C1-C10)-alkyl, (C1-C4)-alkyl-CON(V1)2, -NH2-SO2-(C1-C4)-alkyl-, (C1-C4)-alkyl-COOV1 wherein all V1 represent (C1-C6)-alkyl; Q represents a 6-membered aromatic group; n represents a whole number from 0 to 3; n' represents a whole number 0 or 1; A, B and C represent hydrogen atom; Z is taken among the group including a bond, linear or branched (C1-C6)-alkylene; R1 is taken among the group including hydrogen atom, (C1-C10)-alkyl, (C3-C12)-cycloalkyl, (C2-C10)-alkylene, (C3-C12)-cycloalkylamino-group, benzyl, (C3-C12)-cycloalkenyl, monocyclic, bicyclic or tricyclic aryl wherein indicated alkyl, cycloalkyl, alkenyl, (C3-C12)-cycloalkylamino-group or benzyl are optionally substituted with substitutes taken among the group including (C1-C10)-alkyl, phenyl, benzyl, benzyloxy-group wherein indicated phenyl, benzyl and benzyloxy-group are substituted optionally with (C1-C10)-alkyl and indicated (C3-C12)-cycloalkyl, (C3-C12)-cycloalkenyl, monocyclic, bicyclic or tricyclic aryl are substituted optionally with 1-3 substitutes taken among the group including (C1-C10)-alkyl and benzyl wherein indicated benzyl is substituted optionally with (C1-C10)-alkyl; R2 represents hydrogen atom and under condition that when n' = 0 then ZR1 doesn't means hydrogen atom (H), or to its pharmaceutically acceptable salt or solvate. Also, the invention describes a pharmaceutical composition based on thereof. Invention provides preparing new compounds possessing the useful biological properties.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
21 cl, 5 tbl, 8 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SPIROPYRAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF, METHOD FOR MODULATION OF OPIOID RECEPTOR AND METHOD FOR TREATMENT USING SUCH COMPOUNDS | 2002 |
|
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| NOVEL DERIVATIVE VITRONECTIN RECEPTOR ANTAGONISTS, SYNTHESIS METHOD THEREOF, USE THEREOF AS MEDICINAL AGENT AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID ANTAGONISTS | 2003 |
|
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| CONDENSED TRICYCLIC DERIVATIVES FOR TREATING PSYCHOTIC DISORDERS | 2005 |
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| CONDENSED QUINOLINE DERIVATIVE AND USE THEREOF | 2005 |
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| DERIVATIVE OF 4,4-DIFLUORO-1,2,2,4-TETRAHYDRO-5H-1-BENZAZEPINE AND ITS SALT | 2004 |
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