STIMULATING AGENTS OF GROWTH HORMONE SECRETION Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel compounds of the formula (I) , racemic and diastereomeric mixtures and optical isomers of these compounds and their pharmaceutically acceptable salts and prodrugs where e = 0 or 1; n and w = 1; Y means oxygen atom; R¹ means hydrogen atom, -(CH₂)_t-A¹ where t = 0, 1 or 2; A¹ means phenyl or totally unsaturated 4-8-membered ring having optionally 1-2 hetero- -atoms taken independently among the group including sulfur and nitrogen atom, bicyclic system consisting of totally unsaturated 5- or 6-membered ring having optionally 1- 2 hetero- -atoms as nitrogen atom; in each case A¹ is substituted optionally and independently at one or optionally at both rings if A¹ means bicyclic ring system and has up to two substituents and each substituent is taken among the group including the following groups: F, Cl, Br, OCF₃, (C₁-C₆)-alkyl, phenyl; R² means hydrogen atom, (C₁-C₈)-alkyl where alkyl group is substituted optionally with CF₃; R³ means (C₁-C₅)-alkyl-X¹-(C₀-C₅)- -alkyl-A¹ where X¹ means -O-; values for A¹ are given above; R⁴ means hydrogen atom; X⁴ means hydrogen atom; R⁶ means a residue of the formula (II) X⁵ where a and b = 0; X^5a and (C₁-C₆) each means independently unsubstituted Z¹-alkyl; R⁷ means a bond; R⁸ and each means hydrogen atom. Compounds of the formula (I) are stimulators of growth hormone and can be used for treatment and prophylaxis of patients with osteoporosis. EFFECT: new compounds indicated above, valuable medicinal properties. 94 cl, 183 ex