DERIVATIVES OF BENZENE OR PYRIDINE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2004 - IPC

FIELD: organic chemistry, pharmacy.

SUBSTANCE: invention relates to new derivatives of benzene or pyridine of the formula (I):

wherein R means hydrogen atom (H), (C₁-C₇)-alkyl or halogen atom; R¹ means hydrogen atom (H) or halogen atom under condition that R¹ at position 4 doesn't mean bromine or iodine atom; R² means hydrogen atom (H) or CF₃; R³ means hydrogen atom (H) or (C₁-C₇)-alkyl; R⁴ means hydrogen atom (H), halogen atom, (C₁-C₇)-alkyl and others; R⁵ means hydrogen atom (H) or (C₁-C₇)-alkyl; X means -C(O)N(R⁵)-, -N(R⁵)C(O)- or -C(O)O-; Y means -(CH₂)_n-, -O-, -S-, -SO₂-, -C(O)- or N(R^5')- wherein R^5' means (lower)-alkyl; Z means =N-, -CH= or -C(C1)=; n means a number from 0 to 4; and their pharmaceutically acceptable salts. Compounds of the formula (I) elicit antagonistic activity with regard to neurokinin-1 receptor and can be used in medicine.

EFFECT: valuable medicinal properties of compounds.

8 cl, 34 ex