DERIVATIVES OF 4-PHENYLPYRIDINE N-OXIDES, MEDICINAL AGENT COMPRISING THEREOF Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention describes derivatives of 4-phenylpyridine N-oxides of the general formula (I) and their pharmaceutically acceptable acid-additive salts wherein R means hydrogen atom, lower alkyl or halogen atom; R¹ means hydrogen atom; R² and R^2' mean independently of one another hydrogen, halogen atom, trifluoromethyl group, (lower)-alkoxy-group; or R² and R^2' can mean in common the group -CH=CH-CH=CH- optionally substituted with one or two substitutes taken among lower alkyl or (lower)-alkoxy-group; R³ and R^3' mean independently of one another hydrogen atom, lower alkyl; R⁴ and R^4' mean independently of one another -(CH₂)_mOR⁶ or lower alkyl; or R⁴ and R^4' form in common with N-atom to which they are bound substituted R⁵-cyclic tertiary amine representing pyrrolidine-1-yl, piperidine-1-yl, piperazine-1-yl, morpholine-4-yl or 1,1-dioxomorpholine-4-yl; R⁵ means hydrogen atom, hydroxyl, -COOR³, -N(R³)CO-lower alkyl or -C(O)R³; R⁶ means hydrogen atom, lower alkyl; X means -C(O)N(R⁶)-, -N(R⁶)C(O)-; n = 0, 1, 2, 3 or 4; m = 1, 2 or 3. Also, invention describes a medicinal agent comprising these compounds. Compounds can be used as drugs in treatment or prophylaxis of diseases associated with antagonists of NK-1 receptor.

EFFECT: valuable medicinal properties of agent.

6 cl, 32 ex