PHENYLALANINOLE DERIVATIVES Russian patent published in 2004 - IPC

FIELD: organic chemistry, pharmacy.

SUBSTANCE: invention relates, in particular, to derivatives of phenylalaninol of the formula (I):

wherein X mean group of the formula (X-1): Y means group of the formula (Y-1):

wherein R₁₅ means halogen atom, nitro-group, (lower)-alkyl, perfluoro-(lower)-alkyl; R₁₆ means hydrogen, halogen atom, nitro-group, (lower)-alkyl; R₂₂ and R₂₃ mean independently hydrogen atom, (lower)-alkyl, halogen atom or perfluoro-(lower)-alkyl and at least one radical among radicals R₂₂ and R₂₃ doesn't mean hydrogen atom; R₂₄ means hydrogen atom; or Y means group (y-3) that represents 3-7-membered ring of the formula: wherein R₂₅ means group of the formula R₂₆-(CH₂)_e- wherein R₂₆ means (lower)-alkoxy-group, (lower)-alkylthio-group, (lower)-alkylsulfonyl, (lower)-alkylsulfinyl; Q means group of the formula -(CH₂)_f wherein e means a whole number from 0 to 4; f means a whole number from 1 to 3. Also, invention describes a pharmaceutical composition eliciting an anti-inflammatory activity and comprising compounds described above.

EFFECT: valuable medicinal properties of derivatives and composition.

12 cl, 4 ex