4-PYRIDINYL-N-ACYL-L-PHENYLALANINES Russian patent published in 2006 - IPC C07D213/64 A61P29/00

Abstract RU 2270193 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention proposes 4-pyridinyl-N-acyl-L-phenylalanines of the formula (I) wherein R₁-R₇ have values given in the invention claim. These compounds are inhibitors of VCAM-1 binding with cells expressing VLA-4 and therefore they are used in treatment of diseases with symptoms associated with binding VCAM-1 with cells expressing VLA-4, for example, chronic inflammatory diseases. Proposed compounds are used as a medicinal agent or a pharmaceutical composition in treatment of rheumatic arthritis, cerebrospinal sclerosis and asthma.

EFFECT: valuable medicinal properties of compounds.

51 cl, 3 tbl, 54 ex

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RU 2 270 193 C2

Authors

Kaplan Dzherald L'Juis

Sudduri Achjutarao

Tilli Dzhefferson Rajt

Dates

2006-02-20—Published

2000-11-29—Filed