FIELD: organic chemistry, medicine. SUBSTANCE: invention relates to N-alkanoylphenylalanine derivatives of the formula (I) 
wherein values of radical X, X', Y and Z are given in the invention claim and to their pharmaceutically acceptable salts and esters. Proposed compounds show high antagonistic activity with respect to VLA-4 and can be used for treatment of rheumatic arthritis, disseminated sclerosis, asthma and intestine inflammatory disease. EFFECT: valuable medicinal properties of compounds. 50 cl, 16 tbl, 182 ex
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