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IPC

(21) (22)

Application

2002130229/15, 2002-11-12

(24)

Start date

2002-11-12

(22)

Actual filing date

2002-11-12

(45)

Published

2004-11-20

(72)

Inventor

Grineva N.I.Akhlynina T.V.Gerasimova L.P.Manakova T.E.Krutov A.A.Kulikova V.F.Levina A.S.

(73)

Holder

Gosudarstvennoe Uchrezhdenie Gematologicheskij Nauchnyj Tsentr Ramn

METHOD FOR EFFECTIVE INDUCTION OF APOPTOSIS IN SUSPENSION CULTURE OF TUMOR BONE MARROW CELLS Ph AND LEUKEMIC PATIENT PERIPHERAL BLOOD USING ANTI-SENSE OLIGONUCLEOTIDES SPECIFIC TO MRNA OF GENES INHIBITING APOPTOSIS Russian patent published in 2004 - IPC

Abstract RU 2240125 C2

FIELD: molecular biology, medicine, oncology.

SUBSTANCE: invention relates to development of methods for specific biotherapy of leucosis Ph⁺. Method involves treatment of suspension cultures of cells Ph⁺ with anti-sense oligonucleotides of length 16-26 nucleotide links that are specific to mRNA of oncogen BCR/ABL in combination with anti-sense oligonucleotides to mRNA of other genes blocking apoptosis of cells Ph⁺ distinctive from BCR/ABL. Invention provides the development of the experimental basis for carrying out oligonucleotide genetic therapy of leucosis Ph⁺.

EFFECT: improved induction method.

5 dwg, 4 ex

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RU 2 240 125 C2

Authors

Grineva N.I.

Akhlynina T.V.

Gerasimova L.P.

Manakova T.E.

Krutov A.A.

Kulikova V.F.

Levina A.S.

Dates

2004-11-20—Published

2002-11-12—Filed