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2 481 583

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IPC

G01N33/53(2006-01-01)

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Application

2012108809/15, 2012-03-07

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Start date

2012-03-07

(22)

Actual filing date

2012-03-07

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Published

2013-05-10

(72)

Inventor

Ovsjannikova Elena GeorgievnaIsrapilova Zaira MagomedovnaPopov Evgenij Antonovich

(73)

Holder

Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennaja Meditsinskaja Akademija" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii Vpo Agma Minzdravsotsrazvitija Rossii)

METHOD FOR PREDICTION OF CLINICAL EFFECTIVENESS IN CHRONIC MYELOID LEUKEMIA Russian patent published in 2013 - IPC G01N33/53

Abstract RU 2481583 C1

FIELD: medicine.

SUBSTANCE: what is involved is the immunogenetic analysis of venous blood of the patients with chronic myeloid leukemia treated with a first-generation tyrosine kinase inhibitor, Gleevec. Polymerase chain reaction PCR-SSP is used to identify the genes of the class II HLA system, locus B. If observing any specificities HLA-DRB1*15(02) or HLA-DRB1*16(02), the favourable outcome of chronic myeloid leukemia with an optimal response developing over the control period (6, 12 18 months of therapy) is predicted. In observing the specificities DRB1*11(05) or DRB1* 14(06), the unfavourable outcome of chronic myeloid leukemia with a failure to achieve an optimal response is predicted.

EFFECT: higher accuracy of prediction of the outcome of chronic myeloid leukemia with underlying Gleevec therapy.

9 tbl, 4 ex

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RU 2 481 583 C1

Authors

Ovsjannikova Elena Georgievna

Israpilova Zaira Magomedovna

Popov Evgenij Antonovich

Dates

2013-05-10—Published

2012-03-07—Filed