COMPOUNDS USEFUL AS ANTI-INFLAMMATORY AGENTS Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to new compounds of the formula (I):

wherein Ar₁ means pyrazole that can be substituted with one or some groups R₁, R₂ or R₃; Ar₂ means naphthyl, tetrahydronaphthyl each of that is substituted optionally 0-1 with groups R₂; X means (C₅-C₈)-cycloalkenyl, phenyl optionally substituted with hydroxy-group or (C₁-C₄)-alkoxy-group, furan, pyridinonyl, pyrazolyl, pyridinyl optionally substituted with hydroxy-group or (C₁-C₄)-alkoxy-group, piperidinyl; Y means a bond or saturated branched or unbranched (C₁-C₄)-carbon chain wherein one methylene group is optionally substituted for NH; or Y is substituted optionally and independently with oxo-group; Z means morpholine, o-group, pyridinyl, furanyl, tetrahydrofuranyl, thiomorpholinyl, pentamethylene sulfide, pentamethylene sulfone, secondary or tertiary amine wherein nitrogen atom of amino-group is bond covalently with the following groups taken among (C₁-C₃)-alkyl and (C₁-C₅)-alkoxyalkyl; R₁ means (C₃-C₁₀)-alkyl that is halogenated optionally, partially or completely; R₂ means branched or unbranched (C₁-C₆)-alkyl that is halogenated partially or completely, halogen atom; R₃ means phenyl, pyrimidinyl, pyrazolyl that are substituted with a single branched or unbranched (C₁-C₆)-alkyl, and pyridinyl optionally substituted with (C₁-C₃)-alkoxy-group or amino-group; W means oxygen atom (O), and its pharmaceutically acceptable salts. Compounds of the formula (I) inhibit producing cytokines that allows their applying in pharmaceutical composition for treatment of cytokine-mediated disease.

EFFECT: valuable medicinal properties of compounds and composition.

13 cl, 1 tbl, 17 sch, 38 ex