AROMATIC HETEROCYCLIC COMPOUNDS AS ANTI-INFLAMMATORY AGENTS Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to compounds of the formula (I): wherein Ar₁ means heterocyclic group representing pyrazole that can be substituted with one or some radicals R₁,R₂ or R₃; Ar₂ means phenyl, naphthyl or tetrahydronaphthyl being each of them is substituted optionally with one-three groups R₂; L means saturated or unsaturated branched or linear carbon C₁-C₁₀-chain wherein one or some methylene groups are replaced optionally with oxygen atom, NH or sulfur atom and wherein a binding group is substituted optionally with 0-2 oxo-groups; Q has values taken among the order: (a) phenyl, naphthyl, pyridine, imidazole, pyrane and so on; (b) tetrahydropyrane, morpholine, thiomorpholine, thiomorpholine sulfoxide and so on; (c) secondary or tertiary amino-group wherein nitrogen atom of amino-group is bound covalently with groups taken among C₁-C₃-alkyl, and C₁-C₅-alkoxyalkyl; R₁ has values taken among the row: (a) branched or linear C₃-C₁₀-alkyl and so on; (b) C₃-C₇-cycloalkyl and so on, or tetrahydropyrane group; R₂ represents branched or linear C₁-C₆-alkyl that can be halogenated partially or completely; R₃ is taken among the row including: (a) phenyl, naphthyl and heterocyclic group representing pyridinyl and so on; (b) branched or linear (C₁-C₆)-alkyl that can be halogenated partially or completely and that can be substituted with phenyl group; R₄ and R₅ mean morpholine; X means oxygen atom; and to their physiologically acceptable salts and acids. Invention proposes method for preparing compounds of the formula (I). Also, invention proposes pharmaceutical composition inhibiting producing cytokines comprising compound by cl. 1 or its pharmaceutically acceptable derivatives as an active substance and usual adjuvants. Invention proposes methods for treatment of inflammatory and autoimmune disease that involve administration to patient needing treatment compound by cl. 1 taken in therapeutically effective amount. Invention provides preparing aromatic heterocyclic compounds as anti- -inflammatory agents. EFFECT: valuable medicinal properties of compounds. 17 cl, 16 sch, 3 tbl, 57 ex