FIELD: antibiotics, pharmacy.
SUBSTANCE: invention relates to stabilization of rapamycin or rapamycin derivative with immunosuppressive properties and sensitive to oxidation. Method for stabilization involves addition of antioxidant to the purified rapamycin in small concentrations - below 1% as recalculated for rapamycin mass. Also, invention relates to a solid mixture containing rapamycin and antioxidant taken in the catalytic amount. Antioxidant represent preferably 2,6-di-tert.-butyl-4-methylphenol. The stabilized rapamycin shows high stability against oxidation, it can be stored as formulation without package before it's the following treatment and can be used in an unmodified form for preparing the required galenic composition.
EFFECT: improved stabilizing method.
14 cl, 3 dwg, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 40-O-(2-HYDROXY)ETHYLRAPAMYCIN IN CRYSTALLINE NONSOLVATED FORM, PHARMACEUTICAL COMPOSITION COMPRISING SUCH MACROLIDE AS ACTIVE SUBSTANCE AND METHOD FOR ITS PREPARING | 1999 |
|
RU2264405C2 |
| PHARMACEUTICAL COMPOSITION, USING CARBOXYLIC ACID FOR STABILIZING MACROLIDE IN THIS COMPOSITION AND METHOD FOR STABILIZING MACROLIDE | 1995 |
|
RU2292887C2 |
| PHARMACEUTICAL COMPOSITIONS | 1996 |
|
RU2159107C2 |
| PRELIMINARY PREPARED EMULSION CONCENTRATES CONTAINING CYCLOSPORINE OR MACROLIDE | 1999 |
|
RU2235554C2 |
| MICROEMULSION PRECONCENTRATE | 1995 |
|
RU2181054C2 |
| PHARMACEUTICAL COMPOSITIONS COMPRISING COLLOIDAL SILICON DIOXIDE | 2002 |
|
RU2322970C2 |
| DERIVATIVES OF RAPAMYCIN AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 1996 |
|
RU2158267C2 |
| PHARMACEUTICAL COMPOSITION | 1999 |
|
RU2203058C2 |
| COMPOSITION FOR TOPICAL USE | 1995 |
|
RU2181592C2 |
| APPLICATION OF RAPAMYCIN DERIVATIVES IN VASOPATHY AND XENOTRANSPLANTATION | 1997 |
|
RU2214247C2 |
