FIELD: medicine, pharmacy.
SUBSTANCE: invention describes sterile anesthetic composition for parenteral administration of propofol emulsified in water for injection. The composition comprise above 3 wt.-% but 6 wt.-% of less of solvent not mixing with water. Propofol is dissolved in indicated solvent. The composition is stabilized with 0.2-1.0 wt.-% of surface-active substance and has pH value level in the range 5.0-7.5. The composition with reduced pH value level allows preventing above 10-fold elevating growth of microorganisms for at least 24 h after random external pollution. Reduced fat content in composition also provides the stable analgetic effect for prolonged time and with reduced risk for the blood fat content exceeding.
EFFECT: improved and valuable properties of composition.
15 cl, 4 dwg, 4 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| EMULSIONS "OIL-IN-WATER" CONTAINING PROPOFOL AND EDETATE | 1995 |
|
RU2147432C1 |
| PROPOFOL DELIVERY SYSTEMS | 2016 |
|
RU2709812C2 |
| COMPOSITIONS AND METHODS OF DELIVERY OF PHARMACOLOGICAL AGENTS | 2009 |
|
RU2522977C2 |
| PROPOFOL STABLE CLEAR COMPOSITIONS | 2001 |
|
RU2257892C2 |
| PHENYLACETIC ACID SUBSTITUTED ESTERS AS SHORT-ACTING SEDATIVE SOPOROFIC AGENTS FOR SHORT-TERM ANESTHESIA AND PROVIDING SEDATIVE EFFECT, INTERMEDIATE COMPOUND, PHARMACEUTICAL COMPOSITION AND USING | 2003 |
|
RU2315037C2 |
| COMPOSITIONS AND WAYS OF PHARMACOLOGICAL AGENTS DELIVERY | 2003 |
|
RU2361615C2 |
| MICROCOLLOIDAL SOLUTION OF PROPOFOL FOR ANAESTHESIA | 2013 |
|
RU2535001C1 |
| MANUFACTURE OF MEDICINAL PREPARATIONS BY USING PROPOFOL MICRODROPS | 1997 |
|
RU2186564C2 |
| PHARMACEUTICAL COMPOSITION FOR PARENTERAL DELIVERY IN FORM OF LYOPHILIZATE AND METHOD OF ITS OBTAINING | 2007 |
|
RU2370258C2 |
| ANESTHETIZING FORMULAS | 2001 |
|
RU2250101C2 |
