FIELD: organic chemistry, chemical technology, medicine.
SUBSTANCE: invention relates to synthesis of new biologically active substance, namely, to γ-hydroxypropylammonium-5-hydroxynicotinate of the formula (I): , eliciting an anti-ischemic, anti-arrhythmic and hypolipidemic activity. This compound shows low toxicity and absence of cardiodepressive effect. Compound of the formula (I) is prepared by interaction of 5-hydroxynicotinic acid with 3-amino-1-propanol in the presence of a solvent at heating.
EFFECT: valuable medicinal properties of compound.
1 cl, 7 tbl, 3 ex
Title | Year | Author | Number |
---|---|---|---|
β-HYDROXY ETHYLAMINIUM NICOTINATE DERIVATIVES HAVING ANTIISCHENIC ACTIVITY | 1993 |
|
RU2124502C1 |
2-ETHYL-6-METHYL-3-HYDROXYLIRIDINIUMHYDROXYBUTANEDIOAT EXPRESSING ANTI-ISHEMIC, CEREBROPROTECTIVE, NEUROTROPIC AND LIPID-REGULATING ACTIVITY, PHARMACEUTICAL COMPOSITIONS AND MEDICAL PRODUCT | 2008 |
|
RU2377237C1 |
5-BROMONICOTINIC ACID DERIVATIVES WITH ANTI-ARRHYTHMIC ACTIVITY | 2015 |
|
RU2617428C2 |
ANTI-ISCHEMIC AND ANTI-ATHEROSCLEROTIC DRUG | 1998 |
|
RU2144822C1 |
NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVES AND 5-HYDROXYNICOTINIC ACID SALTS SHOWING ANTIANGINAL AND ANTIARRHYTHMIC PROPERTIES | 1993 |
|
RU2067577C1 |
AGENT EXHIBITING HEPATOPROTECTIVE, LIPID-REGULATING, ANTIISCHEMIC AND NEUROTROPIC ACTIVITY | 2018 |
|
RU2705575C1 |
AGENT POSSESSING ANTIARRHYTHMIC, ANTIFIBRILLATORY, ANTI-ISCHEMIC ACTION, AND BASED PHARMACEUTICAL COMPOSITION | 2011 |
|
RU2477130C1 |
AGENT ELICITING ANTI-ISCHEMIC, HYPOTENSIVE, ANTI- -ARRHYTHMIC AND NOOTROPIC ACTIVITY | 2002 |
|
RU2216322C1 |
CARDIOPROTECTIVE, ANTIARRHYTHMIC ANTI-ISHEMIC AGENT | 2007 |
|
RU2366426C2 |
DIPOTASSIUM SALT OF N-(3-CHLORO-1,4-NAPHTHOQUINOLINE)-2-GLUTAMIC ACID, SHOWING ANTI-HYPOXIA, REDUCTASE, ANTIANGINAL AND ANTI-ISCHEMIA ACTIVITY | 1992 |
|
RU2032661C1 |
Authors
Dates
2005-01-27—Published
2003-09-10—Filed