MEDICINAL AGENT WITH VOLEMIC EFFECT AND METHOD FOR ITS PREPARING Russian patent published in 2005 - IPC

FIELD: medicine, hematology, pharmaceutical technology, pharmacy.

SUBSTANCE: medicinal agent represents hydroxyethylated starch an aqueous solution containing 5-10% of hydroxyethylated starch with the optimal ratio of substituted hydroxyethyl groups at atoms C₂/C₆ up to 6:1 in glucose residue, average value of molecular mass 130-450 kDa, narrowed molecular-mass distribution at the substitution degree 0.35-0.70 and 0.80-1.00% of sodium chloride. Agent is prepared using maize or potato starch as the raw with the content of amylopectin 95%, not less. Starch is subjected for alkaline purification, acidic or enzymatic hydrolysis up to preparing products with molecular mass 400-900 kDa up to the required degree of substitution of hydroxyethyl groups. The solution is purified from impurities by ultrafiltration and/or reverse osmosis and purification is carried out using apyrogenic activated carbon and/or by sterilizing filtration and the following thermal sterilization of the end product. Invention provides preparing a new agent for rapid blood pressure recovery after blood loss.

EFFECT: improved preparing method, valuable medicinal properties of agent.

9 cl, 6 ex