FIELD: pharmacology.
SUBSTANCE: invention refers to a method for producing a dosage form of fluorescein disodium salt preparation (2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid disodium salt) used for angiography in neurosurgery and ophthalmology in the form of 5-10% injection. The method consists in the fact that fluorescein disodium salt is produced by neutralising fluorescein in sodium hydroxide with potentiometric and conductometric monitoring of its efficiency. Disodium salt purity is achieved by cleaning both an intermediate product - fluorescein, and fluorescein sodium salt, using a predetermined combination of conventional cleaning procedures at all the process stages.
EFFECT: method enables producing the dosage form of fluorescein disodium salt preparation with using the more simple and environmentally sound process flow that avoids the stages of synthesis and recovery of fluorescein diacetyl derivative to be hydrolysed in a toxic solvent - methanol on boiling.
2 ex, 4 dwg, 1 tbl
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