FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to a method for preparing 2-hydroxy-4-methylthiobutanoic acid. Method involves the following stages: hydrolysis of 2-hydroxy-4-methylthiobutane nitrile and/or 2-hydroxy-4-methylthiobutaneamide in the presence of sulfuric acid for preparing a reaction mixture containing 2-hydroxy-4-methylthiobutanoic acid; mixing the reaction mixture with an alkaline metal basic compound for preparing a mixture containing an oily layer comprising 2-hydroxy-4-methylthiobutanoic acid and an aqueous layer; isolation of an aoily layer comprising 2-hydroxy-4-methylthiobutanoic acid from the mixture; concentrating an oily layer and removing insoluble material from the concentrated liquid. Invention provides enhanced effectiveness in preparing 2-hydroxy-4-methylthiobutanoic acid being without usage of an organic solvent.
EFFECT: improved preparing method.
3 cl, 3 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF SYNTHESIS OF 2-HYDROXY-4-METHYLTHIO-BUTANOIC ACID | 1998 |
|
RU2184111C2 |
| METHOD FOR PREPARING 2-HYDROXY-4-METHYLTHIO- BUTANOIC ACID | 2000 |
|
RU2213729C2 |
| METHOD FOR CATALYTIC CONVERSION OF 2-HYDROXY-4-METHYLTHIOBUTANE NITRILE (HMTBN) TO 2-HYDROXY-4-METHYLTHIOBUTANE AMIDE (HMTBA) | 2008 |
|
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| METHOD OF PREPARING FLUOXETIN | 1997 |
|
RU2173679C2 |
| METHOD FOR PRODUCTION OF 6-BROM-2-AMINO-4-NITROPHENOL | 1991 |
|
RU2053222C1 |
| SYNTHESIS AND USE OF 2-OXO-4-METHYLTHIOBUTANOIC ACID, SALTS AND DERIVATIVES THEREOF | 2005 |
|
RU2385862C2 |
| 0 |
|
SU425469A1 | |
| METHOD FOR PREPARING HYDROXYMETHYLTHIOBUTYRIC ACID ESTERS | 2000 |
|
RU2230737C2 |
