2-AMINOPYRIDINE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AND METHOD FOR THERAPY Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine.

SUBSTANCE: invention relates to new 2-aminopyridine derivatives of formula I , wherein R¹ is cyano, carboxyl or carbamoyl; R² is hydrogen, hydroxyl, C1-C6-alkoxy or phenyl; R³ and R⁴ are aromatic hydrocarbon such as phenyl or naphthyl, 5-14-membered 5-14-membered optionally substituted aromatic group, excepted cases, when (1) R¹ is cyano, R² is hydrogen, and R³ and R⁴ are simultaneously phenyl;(2) R¹ is cyano, R² is hydrogen, R³ is 4-pyridyl, and R⁴ is 1-pyridyl; (3) R¹ is cyano, R² is 4-methylphenyl, and R³ and R⁴ are simultaneously phenyl;(4) R¹ is cyano, R², R³ and R⁴ are simultaneously phenyl, or salts thereof. Derivatives of present invention have adenosine receptor antagonist activity and are useful in medicine for treatment of irritable bowel syndrome, constipation, and defecation stimulation.

EFFECT: 2-aminopyridine derivatives as adenosine receptor antagonists useful in medicine.

34 cl, 2 tbl, 179 ex