DERIVATIVES OF PYRAZOL PYRIDINE Russian patent published in 2009 - IPC C07D471/04 A61K31/437 A61P35/00 

FIELD: chemistry.

SUBSTANCE: present invention is related to compounds of formula I , which are inhibitors of p38 kinase and may be used in medicine, where A represents N or N⁺O^-; R¹ represents phenyl or heterocyclyl; R² represents heterocyclyl; R³ represents H, carbocyclic radical, aryl or heterocyclyl; R⁴ represents H, R^a, halogen, -OR^a', -CN, -CONR^a'R^a', -NR^a'R^a', -NR^a'COR^a' or -NR^a'CO₂R^a; R⁵ may be connected to any of nitrogens of pyrazole ring of compound in formula I and represents H, alkyl, alkenyl, carbocyclic radical, aryl or heterocyclyl; R^a independently represents alkyl, carbocyclic radical, aryl or heterocyclyl; each R^a' independently represents H or R^a.

EFFECT: preparation of new biologically active compounds.

41 cl, 299 ex, 15 tbl