LIPOSOMAL COMPOSITION, NEUTRAL LIPOPOLYMER AND METHOD FOR ELONGATION OF LIPOSOME CIRCULATING TIME Russian patent published in 2005 - IPC

FIELD: biochemistry.

SUBSTANCE: invention relates to neutral lipopolymer of formula 1 , wherein R¹ and R² independently are alkyl or alkenyl C8-C24-chain; n = 10-300; Z is selected from group consisting of hydroxyl, alkoxyl, benzyloxy, carboxyl acid ester, sulfonic acid ester, alkyl or aryl carbonate, amino, and alkylamino; L is selected from group comprising: (i) X-(C=O)-Y-CH₂-, (ii) -X-(C=O)-, and (iii) -X-CH₂-, wherein X and Y independently are oxygen, NH and direct bond with the proviso, that when L is -X-(C=O)-, X is not NH. Liposomal composition and method for prolongation of liposome circulating time also are disclosed.

EFFECT: neutral lipopolymer providing elongation of liposome circulating time.

11 cl, 5 ex, 6 tbl, 10 dwg