LIPID-BASED PLATINUM COMPOUNDS AND NANOPARTICLES Russian patent published in 2019 - IPC C07F15/00 C07H23/00 C07J41/00 A61K31/282 A61K31/56 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (VIII): Q-linker-lipid (VIII), in which Q represents (I) , where X represents NH or N (CH₂COO^-); and Z is a platinum-containing compound, with platinum forming part of the cycle; (II) , where X is S⁺, C, S⁺=O, N⁺H or P=O; X₁ is -CH-, -CH₂- or -CH₂O-; X₂ represents C=O; and Z is a platinum-containing compound, with platinum forming part of the cycle; (III) , where X₁ represents (CH₂)_n; X₂ represents C=O; Z is a platinum-containing compound, with platinum forming part of the cycle; and n is 0.1 or 2; (IV) , where R₁, R₂ and R₃ are independently halogen, amino, alkylamino, dialkylamino, hydroxyl, thiol, thioalkyl, O-acyl, -linker-lipid, or a combination thereof; or (V) , where R₁, R₂, R₃, R₄ and R₅ are independently halogen, amino, alkylamino, dialkylamino, hydroxyl, thiol, thioalkyl, O-acyl, -linker-lipid, or a combination thereof. Further, the values of the linker and lipid are as indicated in the claims. Also provided are a method for preparing a compound of formula (VIII), a nanoparticle, a pharmaceutical composition, a method for treating or eliminating cancer, a method for producing a nanoparticle.

EFFECT: proposed compounds show a higher absorption of platinum in cancer cells compared to cisplatin and oxaliplatin and can be used to treat or eliminate cancer.

32 cl, 28 dwg, 1 tbl, 10 ex