ANALOGUES OF L-RIBO-CNA Russian patent published in 2005 - IPC

FIELD: organic chemistry, biochemistry.

SUBSTANCE: invention relates to oligomer comprising at least one nucleoside analogue of L-ribo-CNA of the general formula (Ia) wherein X represents -O-; B represents nitrogen base; P means radical position in an internucleoside linkage followed by monomer or 5'-terminal hydroxy-group; P* means an internucleoside linkage with precede monomer or 3'-terminal hydroxy-group; R^2* and R^4* mean in common biradical -(CH₂)_0-1-O-(CH₂)_1-3-(CH₂)_0-1-S-(CH₂)_1-3- or -(CH₂)_0-1-NR-(CH₂)_1-3- wherein R means hydrogen atom, alkyl or acyl; R^1*, R², R^3*, R⁵ and R^5* mean hydrogen atom. Also, invention proposes nucleoside analogues used in preparing oligomers. Proposed oligomers elicit the enhanced affinity to complementary nucleic acids and can be used as a tool in molecular-biological investigations and as antisense, antigen agents of agents activating genes.

EFFECT: valuable properties of analogues.

15 cl, 3 tbl, 4 dwg, 17 ex