FIELD: biotechnology.
SUBSTANCE: invention relates to biotechnology, specifically to a modified oligonucleotide capable of specifically inhibiting the expression of angiopoietin-like protein 3 (ANGPTL3), and can be used in medicine.
EFFECT: invention is applicable for treating, preventing, delaying the progression or alleviation of cardiovascular diseases and/or metabolic diseases associated with a higher level of ANGPTL3.
21 cl, 110 tbl, 16 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOUNDS AND METHODS FOR MODULATING EXPRESSION OF DYSTROPHIC MIOTONIN-PROTEINKINASE (DMPK) | 2014 |
|
RU2690333C2 |
| COMPOSITIONS FOR MODULATING EXPRESSION OF SOD-1 | 2015 |
|
RU2704619C2 |
| MODULATORS OF GROWTH HORMONE RECEPTOR | 2014 |
|
RU2700244C2 |
| COMPOSITIONS FOR MODULATION OF ATAXIN 2 EXPRESSION | 2015 |
|
RU2702838C2 |
| MODULATORS OF COMPLEMENT FACTOR B | 2014 |
|
RU2662967C2 |
| COMPOSITIONS AND METHODS FOR MODULATING PKK EXPRESSION | 2015 |
|
RU2703411C2 |
| ANTISENSE MODULATION OF GCGR EXPRESSION | 2012 |
|
RU2598709C2 |
| COMPOUND FOR MODULATION OF C9ORF72 GENE EXPRESSION AND USE THEREOF | 2013 |
|
RU2730677C2 |
| FACTOR 11 EXPRESSION MODULATION | 2009 |
|
RU2535964C2 |
| COMPOSITION FOR MODULATION OF C90RF72 EXPRESSION | 2014 |
|
RU2748426C2 |
