METHODS FOR STABILIZING BENZIMIDAZOLE-BASE COMPOUNDS Russian patent published in 2005 - IPC

FIELD: organic chemistry.

SUBSTANCE: invention relates to methods for stabilizing compounds based on benzimidazole or its physiologically acceptable salt. One variant of a method involves incorporation of crospovidone having small diameter of particles and at least one compound taken among sodium hydroxide and potassium hydroxide into benzimidazole-base compound represented by the formula (1):

wherein Het¹ means:

Het² means:

R¹ and R² are similar or different and taken among hydrogen atom, methoxy- and difluoromethoxy-group; R³ is taken among hydrogen and sodium atom; R⁴, R⁵ and R⁶ are similar or different and taken among group comprising hydrogen atom, methyl, methoxy-, methoxypropoxy- and trifluoroethoxy-group, or its physiologically acceptable salt. Other variants involve applying at least one compounds taken among sodium hydroxide and potassium hydroxide on core formed by incorporation of crospovidone into benzimidazole-base compound represented by the formula (1) or its physiologically acceptable salt, enteric soluble coating, or intermediate coating and the following applying additional enteric soluble coating on it. Also, invention relates to a method for prevention of the benzimidazole-base compound color change or its physiologically acceptable salts and this method involves incorporation of crospovidone and at least one compound taken among sodium hydroxide and potassium hydroxide into benzimidazole-base compound by cl. 1, or its physiologically acceptable salt.

EFFECT: improved stabilizing method.

7 cl, 2 tbl, 8 ex