FIELD: medicine; pharmacology.
SUBSTANCE: pharmaceutical composition of controlled release, specifically composition of pulse release, includes nucleus containing physiologically active substance, unstable in acidic medium, leavening agent and alkaline additive. Nucleus has release control coating containing water-insoluble polymer, entero-soluble polymer and hydrophobic wax. Amount of hydrophobic wax in coating is 20-35 wt % of release control coating weight. Physiologically active substance, unstable in acidic medium represents compound based on benzimidazole or its pharmaceutically acceptable salt.
EFFECT: invention provides slight delay difference in composition dissolution and dissolution percent with the course of time providing high reliability of dissolution properties.
28 cl, 16 dwg, 23 tbl, 16 ex
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