FIELD: medicine, pharmaceutics.
SUBSTANCE: controlled release solid preparation contains a combination of (1) an antacid, (2) an immediate release portion containing a proton pump inhibitor, preferentially lansoprazole, and a basic substance, and (3) a delayed release portion comprising a proton pump inhibitor and a pH-independent material.
EFFECT: solid preparation according to the invention shows an increase in gastric pH up to 4 or higher 0,5 h after oral administration into a mammal and a retention time at pH 4 or higher for at least 14 hours a day.
16 cl, 8 ex
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