FIELD: organic chemistry, medicine, pharmacology, pharmacy.
SUBSTANCE: invention relates to derivatives of 1,2-dihydropyridine of the general formula (I)
,
their salts or hydrates wherein Q means oxygen atom (O); R1, R2, R3, R4 and R5 are similar or different of one another and each radical means hydrogen atom, halogen atom, (C1-C6)-alkyl group or group represented by the formula: -X-A (wherein X means a simple bond, (C1-C6)-alkylene group); A means (C6-C14)-aromatic hydrocarbocyclic group or 5-14-membered aromatic heterocyclic group. Also, invention describes a method for preparing compounds and pharmaceutical composition. Compounds possess the strong inhibitory effect on AMPA receptors and/or kainate receptors.
EFFECT: improved preparing method, valuable properties of compounds and composition.
99 cl, 1 tbl, 414 ex
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