CONDENSED 4-OXOPYRIMIDINE DERIVATIVE Russian patent published in 2009 - IPC C07D217/24 A61K31/4725 A61K31/517 A61K31/519 A61P3/00 A61P25/00 A61P7/00 

FIELD: chemistry.

SUBSTANCE: in the new compounds with formula I Ar is a bivalent group, formed by removal of two hydrogen atoms from benzol, pyrimidine or pyridine (this bivalent group can also be substituted with a halogen atom, inferior alkoxy (this inferior alkoxy group can also be substituted with a halogen), hydroxyl or inferior alkyl); X¹ is an oxygen atom; R¹ is a straight or branched inferior alkyl (this inferior alkyl group can also be substituted with hydroxy, halogen, alkoxy, allyloxy or aralkyloxy ), phenyl, aralkyl or alkoxy; ring A is a 5- or 6- member heteroaryl ring, containing 1 or 2 nitrogen atoms or a sulphur atom in the ring, or a benzene ring; R² and R³ can be identical or different from each other, and each represents hydrogen, amino, alkylamino, hydroxyl, inferior alkylsulphonyl, halogen, inferior alkyl (this inferior alkyl group can also be substituted with a halogen), inferior cycloalkyl (this inferior cycloalkyl group can also be substituted with a halogen), inferior alkoxy (this inferior alkoxy group can also be substituted with a halogen), aryl, heteroaryl, mono inferior alkylcarbamoyl, inferior alkylcarboxamide, arylcarboxamide, inferior alkylsulphonylamino, alkylaminosulphonyl, aralkyl or alkanoylakylamino or; Y is CH or a nitrogen atom; -X² is a group with formula (II) (where R⁴ and R⁵ and a the nitrogen atom, taken together, can form a 5-8-member monocyclic ring (this monocyclic ring can be substituted with a halogen atom, oxo group or inferior alkyl group, which can be substituted by a halogen itself), or a 6-10-member bicyclo-ring, n is an integer, which assumes values 3 or 4, and (CH₂)_n can be substituted with an inferior alkyl group, containing 1-3 carbon atoms), with formula (III) (where m is and integer which assumes values from 0 to 4, and R⁶ is an inferior alkyl or cycloalkyl group) or formula (IV) , where symbols assume values given above. The invention also relates to agents for preventing or curing metabolic diseases, blood circulatory diseases or diseases of the nervous system, containing formula I compounds.

EFFECT: new compounds can be used in medicine.

18 cl, 279 ex