COMPOSITION COMPRISING L-DOPA TRANSFER BLOCKING AGENTS IN RENAL CELLS AND THEIR USING IN TREATMENT OF PARKINSON'S DISEASE Russian patent published in 2005 - IPC

FIELD: medicine, pharmacy.

SUBSTANCE: invention relates to a pharmaceutical composition used in treatment of Parkinson's disease that comprises L-DOPA and at least one compound able to inhibit the external transfer of L-DOPA in renal cells. Indicated blocking agent is taken among the following substances: flavonoid - a derivative of phenylbenzpyrane, a derivative of trans-stilbene and floretin, i. e. [3-(4-hydroxyphenyl)-1-(2,4-trihydroxyphenyl)-1-propanone]. Also, the composition can comprise inhibitor of enzyme amino acid decarboxylase, such as carbi-DOPA or benzerasid and/or inhibitor of enzyme catechol O-methyltransferase, such as entacapon or tolcapon. The composition can be used in a solid formulation and L-DOPA can be administrated simultaneously or successively with a blocking agent of L-DOPA external transfer in renal cells. Invention provides expanding assortment of agents used in treatment of Parkinson's disease.

EFFECT: valuable medicinal properties of composition.

28 cl, 1 tbl, 5 dwg