SUBSTITUTED 2-PHENYL-1-(3,4-DIHYDROXY-5-NITROPHENYL)-1-ETHANONES, METHOD FOR TREATMENT OF SOME DISTURBANCES IN CENTRAL AND PERIPHERAL NERVOUS SYSTEM AND PHARMACEUTICAL COMPOSITION CONTAINING INDICATED SUBSTANCES Russian patent published in 2004 - IPC

FIELD: organic chemistry, medicine, biochemistry, pharmacy.

SUBSTANCE: invention relates to substituted 2-phenyl-1-(3,4-dihydroxy-5-nitrophenyl)-1-ethanones and describes a compound of the formula (I):

wherein R₁ and R₂ have similar or different values and mean hydrogen atoms or optionally substituted lower alkanoyl; R₃, R₄ and R₅ have similar or different values and mean hydrogen atom, saturated lower hydrocarbon residue, halogen atom or aromatic rings, and its pharmaceutically acceptable salts. Also, invention describes a method for treatment of patient suffering with some disturbances in central and peripheral nervous system when reducing O-methylation of catecholamines can exhibit favorable curative effect on such diseases as Parkinson's disease and disorders relating to parkinsonism, gastrointestinal disorders, edemas and hypertension. Except for, invention describes a pharmaceutical composition eliciting COMT-effect. Invention provides preparing new compounds eliciting with useful biological properties.

EFFECT: valuable medicinal properties of compounds.

7 cl, 6 dwg, 3 tbl, 27 ex