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2 269 538

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IPC

C07D491/147(2006-01-01)

A61K31/519(2006-01-01)

A61P25/00(2006-01-01)

A61P25/28(2006-01-01)

A61P35/00(2006-01-01)

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Application

2004138775/04, 2004-12-30

(24)

Start date

2004-12-30

(22)

Actual filing date

2004-12-30

(45)

Published

2006-02-10

(72)

Inventor

Zhuravel' Irina AleksandrovnaIvashchenko Aleksandr Vasil'EvichKovalenko Sergej NikolaevichBorisov Aleksandr VladimirovichOkun' Il'Ja MatusovichTkachenko Sergej Evgen'EvichChernykh Valentin Petrovich

(73)

Holder

Obshchestvo S Ogranichennoj Otvetstvennost'Ju Institut Khimicheskogo Raznoobrazija" Institut Khimicheskogo Raznoobrazija")

SUBSTITUTED PYRIDO[4',3':5,6]PYRANO[2,3-d]PYRIMIDINES AND COMBINATORY LIBRARY Russian patent published in 2006 - IPC C07D491/147 A61K31/519 A61P25/00 A61P25/28 A61P35/00

Abstract RU 2269538 C1

FIELD: organic chemistry of heterocyclic compounds, biology, medicine, pharmacy.

SUBSTANCE: invention relates to new substituted pyrido[4',3':5,6]pyrano[2,3-d]pyrimidines of the general formula (1): or (2): or their pharmaceutically acceptable salts, N-oxides or hydrate possessing physiologically active properties, in particular, eliciting ability to induce apoptosis in tumor cells causing their death. In the general formula (1) or (2) X represents sulfur or oxygen atom; Y represents sulfur atom, group -SO, group -SO₂, group -NH or group -NR⁶; R¹ represents aryl, substituted aryl, heteroaryl; R² and R⁵ represent hydrogen atom, alkyl, allyl, substituted benzyl, group -CH₂-C(O)R³, group -CH₂-C(O)NR³R⁴ wherein R³, R⁴ and R⁶ represent inert substitute. Also, invention relates to new combinatory libraries for search compound-leaders and candidates for medicinal compounds preparing by screening the combinatory libraries.

EFFECT: valuable medicinal properties of compounds.

9 cl, 1 tbl, 9 ex

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RU 2 269 538 C1

Authors

Zhuravel' Irina Aleksandrovna

Ivashchenko Aleksandr Vasil'Evich

Kovalenko Sergej Nikolaevich

Borisov Aleksandr Vladimirovich

Okun' Il'Ja Matusovich

Tkachenko Sergej Evgen'Evich

Chernykh Valentin Petrovich

Dates

2006-02-10—Published

2004-12-30—Filed